About Our Physician Investigators

Paul K. Holden, MD, MS

M.S. - Biochemistry (University of California, Riverside)

M.D. - Research in Orthopedics and Morphology  (USC in Los Angeles)

Internship and Residency at University of California, Irvine


Dr. Holden has over 20 years of basic science and clinical research experience.  His first work in signal transduction and cellular communication began in 1992 at the University of California.  Since that time, he has worked in various laboratory and medical settings and is a published author on a wide range of basic science and clinical findings.  Dr. Holden has given regional and national presentations on his work and continues to contribute every year.

Dr. Holden has taught college students, residents and physicians on the subjects of science, research and medicine.  He has a passion for scientific exploration.  His career has always maintained a focus on discovery, including the field of plastic and reconstructive surgery.  As he has furthered his work in the surgical arts, he has become even more focused on the body's ability to heal itself and regenerate.  As a result, Dr. Holden has been involved directly in stem cell research since 2012 and continues to be a contributor to the field.

Ryan B. Tsujimura, MD

B.S. - Biology (University of Washington)

M.D. - University of Washington School of Medicine

Research in wound and burn care, flap surgery
Internship at Oregon Health Science Univ., Residency at Mayo Clinic, Phoenix

Dr. Tsujimura attended the University of Washington where he graduated with a Bachelor of Science degree in biology with honors. He completed his medical education at the University of Washington School of Medicine in Seattle WA. At the U of W, he graduated in the top 10% of his medical school class in 1993 and then finished his Internship at Oregon Health Science University in Portland Oregon. Dr. Tsujimura went on the complete his residency at Maricopa Medical Center and Mayo Clinic in Phoenix Arizona from 1994 to 1999 in general surgery.


Prior to attending the University of Tennessee (Memphis Plastic Surgery) from 2000 to 2002, he was an attending surgeon in private practice performing general, trauma, and vascular surgeries, as well as giving back to the field by training future surgeons. To remain on the cutting edge, Dr. Tsujimura is constantly learning new techniques from his colleagues here in the U.S. as well as other countries.